Linking an excel spreadsheet to a networked database

Can someone please tell me if there is a way to have more than one user
working in a database when one of the tables comes from a linked excel
spreadsheet?
I've figured out how to have more than one user working in the same
spreadsheet and I've figured out how to have more than one user working in a
database with the frontend and backend files, information I got from here.
In the sample databases I created everything works great when using only
tables that I create within the database but when I try to make a sample
database with one of the tables coming from a linked spreadsheet then only
one user can get into the database. Is there a way I can get this to work?
I don't want to spend lots of time trying to figure it out if it's not
something that's possible. Thanks for any help you can give me.