Make Table v. Append to Table: Need Some Expert Design Inputs

I am working on updates to a couple related databases (not linked by any
tables) and have a question about virtues of Make Table vs Append queries.

Make Table: I understand that this will create a NEW table where ever it is
pointed,
so if that table already exists in the destination it
will be deleted, and
the new table written in its place.

Append : In this case I understand that it would require a little more
"work" to
do same as Make Table, i.e. clearing out table before
appending data.

The 1st major difference, other than additional steps, I can see is if you
have a table structure you wish to retain the Append qry idea might be more
favorable over the Make table qry.

Okay, now you database gurus...
(1) Are there any other advantages/difierences one over the other?; and
(2) What about database size impacts. grow/shrink, assuming the amount of
data is fairly consistent from time to time of run?

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MJ